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Flickering Technology

MatchedFlicker uses Automated Alternation Flickering technology to produce dramatic "movement" that clearly highlights even the most subtle changes between two images.

Our proprietary technology* works by automatically aligning and registering two images of the same object taken at different points in time, and then generating a superimposed view that is alternated back and forth (i.e., a Flicker™). In so doing, areas of change present between the two images appear as motion.

Flickering technology has been shown to be highly effective for analysis of medical images of the posterior (back) pole of the eye and is an FDA 510(k) class II device.

In several studies the science behind MatchedFlicker has been shown to be superior to side-by-side (SBS) comparison of photographic images:

  • Clinically shown in screening of premature infant eyes for retinopathy of prematurity to cut the analysis time in half without any loss in the ability to detect disease.1
  • In a study published in a leading EU journal, MatchedFlicker was shown to improve the ability of even non-specialists to detect glaucoma by 35%.2
  • In the same study, MatchedFlicker also reduced analysis time by about a third.
  • In another published study looking at very subtle disease progression, use of MatchedFlicker resulted in a nearly 3-fold increase in detection rate and agreement rate among expert clinicians.3

By taking the guesswork out of the alignment and registration process, MatchedFlicker helps to improve both the speed and accuracy, of image diagnostic evaluations. This translates into more efficient workflow, more accurate patient diagnosis, and ease of documentation for busy eye care professionals.

* EyeIC's flickering technology is protected by issued U.S. patents. Other US and international patents pending.

  1. Michael F. Chiang, Jane S. Myung, Rony Gelman, Grant D. Aaker, Nathan M. Radcliffe, Robison V. Chan. Evaluation Of Plus Disease Progression Using Digital Registration Of Multiple Images. Presented at ARVO 2011 Annual Meeting.
  2. Syed, Z. A., Radcliffe, N. M., De Moraes, C. G., Smith, S. D., Liebmann, J. M. and Ritch, R. Automated alternation flicker for the detection of optic disc haemorrhages. Acta Ophthalmologica (2011)
  3. VanderBeek, B. L., Smith, S. D., and Radcliffe, N. M. Comparing the detection and agreement of parapapillary atrophy progression using digital optic disk photographs and alternation flicker. Graefe's Archive for Clinical and Experimental Ophthalmology 248.9 (September 2010): 1313–1317.

Put the technology of MatchedFlicker to the test: